Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniae.
نویسندگان
چکیده
We evaluated pulsatile dosing of clarithromycin and amoxicillin alone or combined against Streptococcus pneumoniae with various susceptibilities. When combined, pulsatile amoxicillin with clarithromycin was superior to either 8- or 12-h dosing against the intermediate strain and was identical for the susceptible strain. Pulse dosing of antimicrobials warrants further investigation.
منابع مشابه
Efficacy of pulsatile amoxicillin and clarithromycin dosing alone and in combination in a murine pneumococcal pneumonia model.
OBJECTIVES Amoxicillin and clarithromycin have been proven to be effective in the treatment of community-acquired pneumonia. This study investigated the in vivo bactericidal efficacy of a novel, pulsatile dosing strategy for amoxicillin and clarithromycin, when used as monotherapy and combination therapy. METHODS A neutropenic murine pneumonia model was used to assess the bactericidal activit...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 2 شماره
صفحات -
تاریخ انتشار 2006